The Comparison of Three Combination Therapies in Lowering Blood Pressure in Black Africans (CREOLE) study is a Multi-centre, multinational, randomized single-blind, parallel-group, three-armed superiority trial.

The primary objective of this study is to compare the efficacy of three “free” combinations of two anti-hypertensive agents on 24-hour ambulatory systolic blood pressure (ASBP) in black African hypertensive patients. These three frontline antihypertensive combinations are Amlodipine plus Perindopril, Amlodipine plus Hydrochlorothiazide and Perindopril plus Hydrochlorothiazide.

This study which is sponsored by GlaxoSmithKline Non-Communicable Disease Grant has the University of Abuja as the co-ordinating site with Dr. Dike Ojji, Senior Lecturer in the Department of Internal Medicine, Faculty of Clinical Sciences, College of Health Sciences being the Principal Investigator.

This study is currently ongoing in ten sites in six countries which include:

  1. University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria
  2. Aminu Kano Teaching Hospital, Kano, Nigeria
  3. University College Hospital, Ibadan, Nigeria
  4. Groote Schuur Hospital/ Khayelitsha Community Health Centre, Cape Town, South Africa
  5. Dr. George Mukhari Hospital, Ga-Rankuwa, Pretoria, South Africa
  6. Douala General Hospital, Douala, Cameroon
  7. University Hospital, Nairobi, Kenya
  8. Moi University Teaching Hospital, Eldoret, Kenya
  9. Eduardo Mondlane University Hospital, Maputo, Mozambique
  10. St. Francis Hospital, Nsambya, Kampala


See link for details on Sites visitations and monitoring